Auvelity

Black Box Warning

Generic: dextromethorphan/bupropion

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Information reviewed July 24, 2026

Rank #81 in US TV Ads
Class: NMDA Antagonist / Aminoketone Combination

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What is it for?

A newer oral antidepressant designed to begin improving depression symptoms relatively quickly.

Primary Condition

Major depressive disorder

How it works

Combines an NMDA receptor modulator with a reuptake inhibitor to act on glutamate and other mood pathways.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Dizziness
  • Headache
  • Diarrhea
  • Sleepiness
  • Suicidal thoughts in young adults

Auvelity FAQs

What is Auvelity used for?

Auvelity (dextromethorphan/bupropion) is a prescription medication used to treat Major depressive disorder. A newer oral antidepressant designed to begin improving depression symptoms relatively quickly.

How does Auvelity work?

Combines an NMDA receptor modulator with a reuptake inhibitor to act on glutamate and other mood pathways.

What are the common side effects of Auvelity?

Commonly reported side effects of Auvelity include Dizziness, Headache, Diarrhea, Sleepiness, and Suicidal thoughts in young adults. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Auvelity have any serious warnings?

Yes. Auvelity carries an FDA Boxed Warning — the agency's most serious safety warning. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.

What is the generic name for Auvelity?

The active ingredient in Auvelity is dextromethorphan/bupropion, which belongs to a class of medicines known as NMDA Antagonist / Aminoketone Combination.

Who makes Auvelity?

Auvelity is manufactured by Axsome Therapeutics. It was first approved in 2022.

How can I save money on Auvelity?

You may be able to lower the cost of Auvelity by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Auvelity

Other Mental Health medications

See more drugs like Auvelity

Quick Facts

Manufacturer

Axsome Therapeutics

Year Approved

2022

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