Benlysta

Moderate Warnings

Generic: belimumab

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Information reviewed July 24, 2026

Rank #140 in US TV Ads
Class: BLyS-Specific Inhibitor (Biologic)

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What is it for?

A treatment for lupus and lupus nephritis, available as an infusion or a self-injection, used alongside other lupus medicines.

Primary Condition

Lupus (systemic lupus erythematosus)

How it works

A B-lymphocyte stimulator (BLyS) inhibitor that reduces the abnormal immune cells that contribute to lupus activity.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Nausea
  • Diarrhea
  • Fever
  • Infusion or injection reactions
  • Increased infection risk

Benlysta FAQs

What is Benlysta used for?

Benlysta (belimumab) is a prescription medication used to treat Lupus (systemic lupus erythematosus). A treatment for lupus and lupus nephritis, available as an infusion or a self-injection, used alongside other lupus medicines.

How does Benlysta work?

A B-lymphocyte stimulator (BLyS) inhibitor that reduces the abnormal immune cells that contribute to lupus activity.

What are the common side effects of Benlysta?

Commonly reported side effects of Benlysta include Nausea, Diarrhea, Fever, Infusion or injection reactions, and Increased infection risk. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Benlysta have any serious warnings?

Benlysta has notable warnings and precautions. Tell your doctor about your medical history and any other medicines or supplements you take before starting Benlysta.

What is the generic name for Benlysta?

The active ingredient in Benlysta is belimumab, which belongs to a class of medicines known as BLyS-Specific Inhibitor (Biologic).

Who makes Benlysta?

Benlysta is manufactured by GSK. It was first approved in 2011.

How can I save money on Benlysta?

You may be able to lower the cost of Benlysta by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Benlysta

Other Autoimmune medications

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Quick Facts

Manufacturer

GSK

Year Approved

2011

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