Caplyta

Black Box Warning

Generic: lumateperone

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Information reviewed July 24, 2026

Rank #30 in US TV Ads
Class: Atypical Antipsychotic

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What is it for?

A once-daily oral antipsychotic for schizophrenia and for depressive episodes of bipolar I and II disorder.

Primary Condition

Schizophrenia, bipolar depression

How it works

Acts on serotonin, dopamine, and glutamate pathways to help stabilize mood and reduce psychotic symptoms.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Drowsiness
  • Dry mouth
  • Dizziness
  • Nausea
  • Increased mortality in dementia patients

Caplyta FAQs

What is Caplyta used for?

Caplyta (lumateperone) is a prescription medication used to treat Schizophrenia, bipolar depression. A once-daily oral antipsychotic for schizophrenia and for depressive episodes of bipolar I and II disorder.

How does Caplyta work?

Acts on serotonin, dopamine, and glutamate pathways to help stabilize mood and reduce psychotic symptoms.

What are the common side effects of Caplyta?

Commonly reported side effects of Caplyta include Drowsiness, Dry mouth, Dizziness, Nausea, and Increased mortality in dementia patients. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Caplyta have any serious warnings?

Yes. Caplyta carries an FDA Boxed Warning — the agency's most serious safety warning. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.

What is the generic name for Caplyta?

The active ingredient in Caplyta is lumateperone, which belongs to a class of medicines known as Atypical Antipsychotic.

Who makes Caplyta?

Caplyta is manufactured by Intra-Cellular Therapies. It was first approved in 2019.

How can I save money on Caplyta?

You may be able to lower the cost of Caplyta by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Caplyta

Other Mental Health medications

See more drugs like Caplyta

Quick Facts

Manufacturer

Intra-Cellular Therapies

Year Approved

2019

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