Enbrel

Black Box Warning

Generic: etanercept

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Information reviewed July 24, 2026

Rank #132 in US TV Ads
Class: TNF Blocker (Biologic)

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What is it for?

A long-running self-injected biologic for rheumatoid arthritis, plaque psoriasis, and psoriatic arthritis, known for its widely-run TV campaigns.

Primary Condition

Rheumatoid arthritis and plaque psoriasis

How it works

A TNF blocker that neutralizes tumor necrosis factor, a protein that drives the inflammation behind these autoimmune conditions.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Serious infections
  • Injection-site reactions
  • Headache
  • Increased cancer risk
  • Higher risk of tuberculosis

Enbrel FAQs

What is Enbrel used for?

Enbrel (etanercept) is a prescription medication used to treat Rheumatoid arthritis and plaque psoriasis. A long-running self-injected biologic for rheumatoid arthritis, plaque psoriasis, and psoriatic arthritis, known for its widely-run TV campaigns.

How does Enbrel work?

A TNF blocker that neutralizes tumor necrosis factor, a protein that drives the inflammation behind these autoimmune conditions.

What are the common side effects of Enbrel?

Commonly reported side effects of Enbrel include Serious infections, Injection-site reactions, Headache, Increased cancer risk, and Higher risk of tuberculosis. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Enbrel have any serious warnings?

Yes. Enbrel carries an FDA Boxed Warning — the agency's most serious safety warning. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.

What is the generic name for Enbrel?

The active ingredient in Enbrel is etanercept, which belongs to a class of medicines known as TNF Blocker (Biologic).

Who makes Enbrel?

Enbrel is manufactured by Amgen. It was first approved in 1998.

How can I save money on Enbrel?

You may be able to lower the cost of Enbrel by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Enbrel

Other Autoimmune medications

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Quick Facts

Manufacturer

Amgen

Year Approved

1998

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