Entresto

Black Box Warning

Generic: sacubitril/valsartan

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Information reviewed July 24, 2026

Rank #13 in US TV Ads
Class: ARNI (Neprilysin Inhibitor + ARB)

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What is it for?

A twice-daily pill for chronic heart failure that reduces the risk of cardiovascular death and hospitalization.

Primary Condition

Chronic heart failure

How it works

Combines a neprilysin inhibitor with an angiotensin receptor blocker to relax blood vessels and reduce strain on the heart.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Low blood pressure
  • High potassium
  • Kidney problems
  • Dizziness
  • Cough
  • Harm to a fetus

Entresto FAQs

What is Entresto used for?

Entresto (sacubitril/valsartan) is a prescription medication used to treat Chronic heart failure. A twice-daily pill for chronic heart failure that reduces the risk of cardiovascular death and hospitalization.

How does Entresto work?

Combines a neprilysin inhibitor with an angiotensin receptor blocker to relax blood vessels and reduce strain on the heart.

What are the common side effects of Entresto?

Commonly reported side effects of Entresto include Low blood pressure, High potassium, Kidney problems, Dizziness, Cough, and Harm to a fetus. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Entresto have any serious warnings?

Yes. Entresto carries an FDA Boxed Warning — the agency's most serious safety warning. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.

What is the generic name for Entresto?

The active ingredient in Entresto is sacubitril/valsartan, which belongs to a class of medicines known as ARNI (Neprilysin Inhibitor + ARB).

Who makes Entresto?

Entresto is manufactured by Novartis. It was first approved in 2015.

How can I save money on Entresto?

You may be able to lower the cost of Entresto by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Entresto

Other Cardiovascular medications

See more drugs like Entresto

Quick Facts

Manufacturer

Novartis

Year Approved

2015

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