Ibrance

Moderate Warnings

Generic: palbociclib

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Information reviewed July 24, 2026

Rank #27 in US TV Ads
Class: CDK4/6 Inhibitor

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What is it for?

An oral therapy for hormone-receptor-positive, HER2-negative metastatic breast cancer, taken with hormone therapy.

Primary Condition

HR+/HER2- breast cancer

How it works

Blocks CDK4/6 enzymes to interrupt the cell cycle that drives breast cancer cell division.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Low white blood cell count
  • Infections
  • Fatigue
  • Nausea
  • Hair thinning
  • Lung inflammation

Ibrance FAQs

What is Ibrance used for?

Ibrance (palbociclib) is a prescription medication used to treat HR+/HER2- breast cancer. An oral therapy for hormone-receptor-positive, HER2-negative metastatic breast cancer, taken with hormone therapy.

How does Ibrance work?

Blocks CDK4/6 enzymes to interrupt the cell cycle that drives breast cancer cell division.

What are the common side effects of Ibrance?

Commonly reported side effects of Ibrance include Low white blood cell count, Infections, Fatigue, Nausea, Hair thinning, and Lung inflammation. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Ibrance have any serious warnings?

Ibrance has notable warnings and precautions. Tell your doctor about your medical history and any other medicines or supplements you take before starting Ibrance.

What is the generic name for Ibrance?

The active ingredient in Ibrance is palbociclib, which belongs to a class of medicines known as CDK4/6 Inhibitor.

Who makes Ibrance?

Ibrance is manufactured by Pfizer. It was first approved in 2015.

How can I save money on Ibrance?

You may be able to lower the cost of Ibrance by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Ibrance

Other Oncology medications

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Quick Facts

Manufacturer

Pfizer

Year Approved

2015

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