Ibsrela

Black Box Warning

Generic: tenapanor

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Information reviewed July 24, 2026

Rank #118 in US TV Ads
Class: Sodium/Hydrogen Exchanger 3 (NHE3) Inhibitor

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What is it for?

A twice-daily pill for adults with irritable bowel syndrome with constipation (IBS-C).

Primary Condition

Irritable bowel syndrome with constipation (IBS-C)

How it works

Blocks the NHE3 transporter in the gut, increasing fluid in the intestines to ease bowel movements and reduce pain.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Diarrhea
  • Should not be used in young children (boxed warning)
  • Gas
  • Abdominal pain

Ibsrela FAQs

What is Ibsrela used for?

Ibsrela (tenapanor) is a prescription medication used to treat Irritable bowel syndrome with constipation (IBS-C). A twice-daily pill for adults with irritable bowel syndrome with constipation (IBS-C).

How does Ibsrela work?

Blocks the NHE3 transporter in the gut, increasing fluid in the intestines to ease bowel movements and reduce pain.

What are the common side effects of Ibsrela?

Commonly reported side effects of Ibsrela include Diarrhea, Should not be used in young children (boxed warning), Gas, and Abdominal pain. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Ibsrela have any serious warnings?

Yes. Ibsrela carries an FDA Boxed Warning — the agency's most serious safety warning. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.

What is the generic name for Ibsrela?

The active ingredient in Ibsrela is tenapanor, which belongs to a class of medicines known as Sodium/Hydrogen Exchanger 3 (NHE3) Inhibitor.

Who makes Ibsrela?

Ibsrela is manufactured by Ardelyx. It was first approved in 2019.

How can I save money on Ibsrela?

You may be able to lower the cost of Ibsrela by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Ibsrela

Other Gastrointestinal medications

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Quick Facts

Manufacturer

Ardelyx

Year Approved

2019

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