Icotyde

Icotyde (icotrokinra) is a prescription medication used to treat Plaque psoriasis. A first-of-its-kind once-daily pill for moderate-to-severe plaque psoriasis, approved in 2026 for adults and children 12 and older, offering a targeted oral alternative to injectable biologics.

An oral peptide that blocks the interleukin-23 (IL-23) receptor, interrupting the inflammatory signaling that drives plaque psoriasis.

Commonly reported side effects of Icotyde include Headache, Nausea, Cough, Fungal infection, and Fatigue. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Icotyde has notable warnings and precautions. Tell your doctor about your medical history and any other medicines or supplements you take before starting Icotyde.

The active ingredient in Icotyde is icotrokinra, which belongs to a class of medicines known as Oral IL-23 Receptor Antagonist (Peptide).

Icotyde is manufactured by Johnson & Johnson. It was first approved in 2026.

You may be able to lower the cost of Icotyde by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.