Jakafi

Moderate Warnings

Generic: ruxolitinib

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Information reviewed July 24, 2026

Rank #135 in US TV Ads
Class: JAK1/2 Inhibitor

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What is it for?

An oral treatment for certain bone-marrow cancers including myelofibrosis and polycythemia vera, as well as graft-versus-host disease.

Primary Condition

Myelofibrosis and polycythemia vera

How it works

A JAK1/2 inhibitor that blocks overactive Janus kinase signaling, which drives the abnormal blood-cell production in these conditions.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Low blood counts
  • Bruising
  • Dizziness
  • Headache
  • Increased infection risk

Jakafi FAQs

What is Jakafi used for?

Jakafi (ruxolitinib) is a prescription medication used to treat Myelofibrosis and polycythemia vera. An oral treatment for certain bone-marrow cancers including myelofibrosis and polycythemia vera, as well as graft-versus-host disease.

How does Jakafi work?

A JAK1/2 inhibitor that blocks overactive Janus kinase signaling, which drives the abnormal blood-cell production in these conditions.

What are the common side effects of Jakafi?

Commonly reported side effects of Jakafi include Low blood counts, Bruising, Dizziness, Headache, and Increased infection risk. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Jakafi have any serious warnings?

Jakafi has notable warnings and precautions. Tell your doctor about your medical history and any other medicines or supplements you take before starting Jakafi.

What is the generic name for Jakafi?

The active ingredient in Jakafi is ruxolitinib, which belongs to a class of medicines known as JAK1/2 Inhibitor.

Who makes Jakafi?

Jakafi is manufactured by Incyte. It was first approved in 2011.

How can I save money on Jakafi?

You may be able to lower the cost of Jakafi by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Jakafi

Other Oncology medications

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Quick Facts

Manufacturer

Incyte

Year Approved

2011

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