Linzess

Black Box Warning

Generic: linaclotide

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Information reviewed July 24, 2026

Rank #35 in US TV Ads
Class: Guanylate Cyclase-C Agonist

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What is it for?

A once-daily capsule for IBS with constipation and chronic idiopathic constipation in adults.

Primary Condition

Irritable bowel syndrome with constipation, chronic constipation

How it works

Activates intestinal receptors (guanylate cyclase-C) that increase fluid in the gut and speed bowel movements.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Diarrhea
  • Abdominal pain
  • Gas
  • Bloating
  • Not for use in young children

Linzess FAQs

What is Linzess used for?

Linzess (linaclotide) is a prescription medication used to treat Irritable bowel syndrome with constipation, chronic constipation. A once-daily capsule for IBS with constipation and chronic idiopathic constipation in adults.

How does Linzess work?

Activates intestinal receptors (guanylate cyclase-C) that increase fluid in the gut and speed bowel movements.

What are the common side effects of Linzess?

Commonly reported side effects of Linzess include Diarrhea, Abdominal pain, Gas, Bloating, and Not for use in young children. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Linzess have any serious warnings?

Yes. Linzess carries an FDA Boxed Warning — the agency's most serious safety warning. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.

What is the generic name for Linzess?

The active ingredient in Linzess is linaclotide, which belongs to a class of medicines known as Guanylate Cyclase-C Agonist.

Who makes Linzess?

Linzess is manufactured by AbbVie/Ironwood. It was first approved in 2012.

How can I save money on Linzess?

You may be able to lower the cost of Linzess by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Linzess

Other Gastrointestinal medications

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Quick Facts

Manufacturer

AbbVie/Ironwood

Year Approved

2012

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