Motegrity

Moderate Warnings

Generic: prucalopride

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Information reviewed July 24, 2026

Rank #149 in US TV Ads
Class: Serotonin-4 Receptor Agonist

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What is it for?

A once-daily pill for chronic idiopathic constipation, the long-term form of constipation without a known cause.

Primary Condition

Chronic idiopathic constipation

How it works

A serotonin-4 receptor agonist that stimulates the muscles of the gut to move stool through the colon more regularly.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Headache
  • Abdominal pain
  • Nausea
  • Diarrhea
  • Mood changes

Motegrity FAQs

What is Motegrity used for?

Motegrity (prucalopride) is a prescription medication used to treat Chronic idiopathic constipation. A once-daily pill for chronic idiopathic constipation, the long-term form of constipation without a known cause.

How does Motegrity work?

A serotonin-4 receptor agonist that stimulates the muscles of the gut to move stool through the colon more regularly.

What are the common side effects of Motegrity?

Commonly reported side effects of Motegrity include Headache, Abdominal pain, Nausea, Diarrhea, and Mood changes. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Motegrity have any serious warnings?

Motegrity has notable warnings and precautions. Tell your doctor about your medical history and any other medicines or supplements you take before starting Motegrity.

What is the generic name for Motegrity?

The active ingredient in Motegrity is prucalopride, which belongs to a class of medicines known as Serotonin-4 Receptor Agonist.

Who makes Motegrity?

Motegrity is manufactured by Takeda. It was first approved in 2018.

How can I save money on Motegrity?

You may be able to lower the cost of Motegrity by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Motegrity

Other Gastrointestinal medications

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Quick Facts

Manufacturer

Takeda

Year Approved

2018

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