Nuplazid

Black Box Warning

Generic: pimavanserin

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Information reviewed July 24, 2026

Rank #153 in US TV Ads
Class: Atypical Antipsychotic

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What is it for?

A once-daily pill for hallucinations and delusions associated with Parkinson's disease psychosis.

Primary Condition

Parkinson's disease psychosis

How it works

Targets serotonin 5-HT2A receptors to reduce psychosis symptoms without the dopamine-blocking effects of typical antipsychotics.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Increased mortality in elderly dementia patients
  • Swelling
  • Nausea
  • Confusion
  • Irregular heartbeat (QT prolongation)

Nuplazid FAQs

What is Nuplazid used for?

Nuplazid (pimavanserin) is a prescription medication used to treat Parkinson's disease psychosis. A once-daily pill for hallucinations and delusions associated with Parkinson's disease psychosis.

How does Nuplazid work?

Targets serotonin 5-HT2A receptors to reduce psychosis symptoms without the dopamine-blocking effects of typical antipsychotics.

What are the common side effects of Nuplazid?

Commonly reported side effects of Nuplazid include Increased mortality in elderly dementia patients, Swelling, Nausea, Confusion, and Irregular heartbeat (QT prolongation). This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Nuplazid have any serious warnings?

Yes. Nuplazid carries an FDA Boxed Warning — the agency's most serious safety warning. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.

What is the generic name for Nuplazid?

The active ingredient in Nuplazid is pimavanserin, which belongs to a class of medicines known as Atypical Antipsychotic.

Who makes Nuplazid?

Nuplazid is manufactured by Acadia Pharmaceuticals. It was first approved in 2016.

How can I save money on Nuplazid?

You may be able to lower the cost of Nuplazid by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Nuplazid

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Quick Facts

Manufacturer

Acadia Pharmaceuticals

Year Approved

2016

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