Orilissa

Moderate Warnings

Generic: elagolix

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Information reviewed July 24, 2026

Rank #93 in US TV Ads
Class: GnRH Antagonist

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What is it for?

An oral medication specifically for moderate-to-severe pain caused by endometriosis.

Primary Condition

Endometriosis pain

How it works

Lowers estrogen by blocking GnRH receptors, reducing the hormone-driven pain of endometriosis.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Hot flashes
  • Headache
  • Nausea
  • Bone density loss
  • Mood changes

Orilissa FAQs

What is Orilissa used for?

Orilissa (elagolix) is a prescription medication used to treat Endometriosis pain. An oral medication specifically for moderate-to-severe pain caused by endometriosis.

How does Orilissa work?

Lowers estrogen by blocking GnRH receptors, reducing the hormone-driven pain of endometriosis.

What are the common side effects of Orilissa?

Commonly reported side effects of Orilissa include Hot flashes, Headache, Nausea, Bone density loss, and Mood changes. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Orilissa have any serious warnings?

Orilissa has notable warnings and precautions. Tell your doctor about your medical history and any other medicines or supplements you take before starting Orilissa.

What is the generic name for Orilissa?

The active ingredient in Orilissa is elagolix, which belongs to a class of medicines known as GnRH Antagonist.

Who makes Orilissa?

Orilissa is manufactured by AbbVie. It was first approved in 2018.

How can I save money on Orilissa?

You may be able to lower the cost of Orilissa by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Orilissa

Other Women's Health medications

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Quick Facts

Manufacturer

AbbVie

Year Approved

2018

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