Otezla

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Generic: apremilast

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Information reviewed July 24, 2026

Rank #21 in US TV Ads
Class: PDE4 Inhibitor

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What is it for?

An oral pill for plaque psoriasis, psoriatic arthritis, and oral ulcers of Behçet's disease, with no required lab monitoring.

Primary Condition

Plaque psoriasis, psoriatic arthritis, Behçet's disease

How it works

Inhibits the enzyme PDE4 inside immune cells, lowering the production of inflammatory chemicals.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Diarrhea
  • Nausea
  • Headache
  • Weight loss
  • Depression
  • Upper respiratory infection

Otezla FAQs

What is Otezla used for?

Otezla (apremilast) is a prescription medication used to treat Plaque psoriasis, psoriatic arthritis, Behçet's disease. An oral pill for plaque psoriasis, psoriatic arthritis, and oral ulcers of Behçet's disease, with no required lab monitoring.

How does Otezla work?

Inhibits the enzyme PDE4 inside immune cells, lowering the production of inflammatory chemicals.

What are the common side effects of Otezla?

Commonly reported side effects of Otezla include Diarrhea, Nausea, Headache, Weight loss, Depression, and Upper respiratory infection. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Otezla have any serious warnings?

Otezla does not carry an FDA Boxed Warning, but every prescription medicine has risks and possible interactions. Always follow your doctor's instructions and read the medication guide that comes with it.

What is the generic name for Otezla?

The active ingredient in Otezla is apremilast, which belongs to a class of medicines known as PDE4 Inhibitor.

Who makes Otezla?

Otezla is manufactured by Amgen. It was first approved in 2014.

How can I save money on Otezla?

You may be able to lower the cost of Otezla by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Otezla

Other Autoimmune medications

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Quick Facts

Manufacturer

Amgen

Year Approved

2014

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