Prolia

Moderate Warnings

Generic: denosumab

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Information reviewed July 24, 2026

Rank #63 in US TV Ads
Class: RANKL Inhibitor (Biologic)

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What is it for?

A twice-yearly injection for osteoporosis in postmenopausal women and others at high risk of fractures.

Primary Condition

Osteoporosis

How it works

Blocks RANKL, a signal that tells the body to break down bone, so bone density is preserved.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Low blood calcium
  • Serious infections
  • Back and joint pain
  • Skin reactions
  • Rare jaw bone problems

Prolia FAQs

What is Prolia used for?

Prolia (denosumab) is a prescription medication used to treat Osteoporosis. A twice-yearly injection for osteoporosis in postmenopausal women and others at high risk of fractures.

How does Prolia work?

Blocks RANKL, a signal that tells the body to break down bone, so bone density is preserved.

What are the common side effects of Prolia?

Commonly reported side effects of Prolia include Low blood calcium, Serious infections, Back and joint pain, Skin reactions, and Rare jaw bone problems. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Prolia have any serious warnings?

Prolia has notable warnings and precautions. Tell your doctor about your medical history and any other medicines or supplements you take before starting Prolia.

What is the generic name for Prolia?

The active ingredient in Prolia is denosumab, which belongs to a class of medicines known as RANKL Inhibitor (Biologic).

Who makes Prolia?

Prolia is manufactured by Amgen. It was first approved in 2010.

How can I save money on Prolia?

You may be able to lower the cost of Prolia by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Prolia

Other Bone Health medications

See more drugs like Prolia

Quick Facts

Manufacturer

Amgen

Year Approved

2010

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