Rexulti

Black Box Warning

Generic: brexpiprazole

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Information reviewed July 24, 2026

Rank #29 in US TV Ads
Class: Atypical Antipsychotic

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What is it for?

An oral antipsychotic used as an add-on for major depression, for schizophrenia, and for agitation with Alzheimer's dementia.

Primary Condition

Major depression (add-on), schizophrenia, agitation in dementia

How it works

Modulates dopamine and serotonin receptor activity to help regulate mood and reduce psychotic symptoms.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Weight gain
  • Restlessness
  • Drowsiness
  • Movement disorders
  • Increased mortality in dementia patients

Rexulti FAQs

What is Rexulti used for?

Rexulti (brexpiprazole) is a prescription medication used to treat Major depression (add-on), schizophrenia, agitation in dementia. An oral antipsychotic used as an add-on for major depression, for schizophrenia, and for agitation with Alzheimer's dementia.

How does Rexulti work?

Modulates dopamine and serotonin receptor activity to help regulate mood and reduce psychotic symptoms.

What are the common side effects of Rexulti?

Commonly reported side effects of Rexulti include Weight gain, Restlessness, Drowsiness, Movement disorders, and Increased mortality in dementia patients. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Rexulti have any serious warnings?

Yes. Rexulti carries an FDA Boxed Warning — the agency's most serious safety warning. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.

What is the generic name for Rexulti?

The active ingredient in Rexulti is brexpiprazole, which belongs to a class of medicines known as Atypical Antipsychotic.

Who makes Rexulti?

Rexulti is manufactured by Otsuka/Lundbeck. It was first approved in 2015.

How can I save money on Rexulti?

You may be able to lower the cost of Rexulti by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Rexulti

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Quick Facts

Manufacturer

Otsuka/Lundbeck

Year Approved

2015

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