Rezdiffra

Moderate Warnings

Generic: resmetirom

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Information reviewed July 24, 2026

Rank #99 in US TV Ads
Class: Thyroid Hormone Receptor-Beta Agonist

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What is it for?

The first FDA-approved treatment for MASH (formerly NASH), a serious form of fatty liver disease with inflammation and scarring.

Primary Condition

Metabolic dysfunction-associated steatohepatitis (MASH)

How it works

Activates thyroid hormone receptor-beta in the liver, helping reduce the buildup of fat that drives inflammation and scarring.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Diarrhea
  • Nausea
  • Itching
  • Gallbladder problems

Rezdiffra FAQs

What is Rezdiffra used for?

Rezdiffra (resmetirom) is a prescription medication used to treat Metabolic dysfunction-associated steatohepatitis (MASH). The first FDA-approved treatment for MASH (formerly NASH), a serious form of fatty liver disease with inflammation and scarring.

How does Rezdiffra work?

Activates thyroid hormone receptor-beta in the liver, helping reduce the buildup of fat that drives inflammation and scarring.

What are the common side effects of Rezdiffra?

Commonly reported side effects of Rezdiffra include Diarrhea, Nausea, Itching, and Gallbladder problems. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Rezdiffra have any serious warnings?

Rezdiffra has notable warnings and precautions. Tell your doctor about your medical history and any other medicines or supplements you take before starting Rezdiffra.

What is the generic name for Rezdiffra?

The active ingredient in Rezdiffra is resmetirom, which belongs to a class of medicines known as Thyroid Hormone Receptor-Beta Agonist.

Who makes Rezdiffra?

Rezdiffra is manufactured by Madrigal Pharmaceuticals. It was first approved in 2024.

How can I save money on Rezdiffra?

You may be able to lower the cost of Rezdiffra by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Rezdiffra

Other Gastrointestinal medications

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Quick Facts

Manufacturer

Madrigal Pharmaceuticals

Year Approved

2024

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