Trintellix

Black Box Warning

Generic: vortioxetine

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Information reviewed July 24, 2026

Rank #36 in US TV Ads
Class: Serotonin Modulator (Antidepressant)

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What is it for?

An oral antidepressant for major depressive disorder in adults, taken once daily.

Primary Condition

Major depressive disorder

How it works

Increases serotonin activity by blocking its reuptake and directly modulating several serotonin receptors.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Nausea
  • Sexual problems
  • Constipation
  • Vomiting
  • Suicidal thoughts in young adults

Trintellix FAQs

What is Trintellix used for?

Trintellix (vortioxetine) is a prescription medication used to treat Major depressive disorder. An oral antidepressant for major depressive disorder in adults, taken once daily.

How does Trintellix work?

Increases serotonin activity by blocking its reuptake and directly modulating several serotonin receptors.

What are the common side effects of Trintellix?

Commonly reported side effects of Trintellix include Nausea, Sexual problems, Constipation, Vomiting, and Suicidal thoughts in young adults. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Trintellix have any serious warnings?

Yes. Trintellix carries an FDA Boxed Warning — the agency's most serious safety warning. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.

What is the generic name for Trintellix?

The active ingredient in Trintellix is vortioxetine, which belongs to a class of medicines known as Serotonin Modulator (Antidepressant).

Who makes Trintellix?

Trintellix is manufactured by Takeda/Lundbeck. It was first approved in 2013.

How can I save money on Trintellix?

You may be able to lower the cost of Trintellix by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Trintellix

Other Mental Health medications

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Quick Facts

Manufacturer

Takeda/Lundbeck

Year Approved

2013

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