Trulance

Black Box Warning

Generic: plecanatide

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Information reviewed July 24, 2026

Rank #117 in US TV Ads
Class: Guanylate Cyclase-C Agonist

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What is it for?

A once-daily pill for chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults.

Primary Condition

Chronic constipation and IBS-C

How it works

A guanylate cyclase-C agonist that increases fluid in the intestines to help stools pass more easily.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Diarrhea
  • Should not be used in young children (boxed warning)
  • Abdominal pain
  • Bloating

Trulance FAQs

What is Trulance used for?

Trulance (plecanatide) is a prescription medication used to treat Chronic constipation and IBS-C. A once-daily pill for chronic idiopathic constipation and irritable bowel syndrome with constipation (IBS-C) in adults.

How does Trulance work?

A guanylate cyclase-C agonist that increases fluid in the intestines to help stools pass more easily.

What are the common side effects of Trulance?

Commonly reported side effects of Trulance include Diarrhea, Should not be used in young children (boxed warning), Abdominal pain, and Bloating. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Trulance have any serious warnings?

Yes. Trulance carries an FDA Boxed Warning — the agency's most serious safety warning. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.

What is the generic name for Trulance?

The active ingredient in Trulance is plecanatide, which belongs to a class of medicines known as Guanylate Cyclase-C Agonist.

Who makes Trulance?

Trulance is manufactured by Salix (Bausch Health). It was first approved in 2017.

How can I save money on Trulance?

You may be able to lower the cost of Trulance by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Trulance

Other Gastrointestinal medications

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Quick Facts

Manufacturer

Salix (Bausch Health)

Year Approved

2017

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