Xifaxan

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Generic: rifaximin

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Information reviewed July 24, 2026

Rank #55 in US TV Ads
Class: Gut-Selective Antibiotic

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What is it for?

A heavily advertised gut-targeted antibiotic used for IBS with diarrhea and to prevent confusion episodes from liver disease.

Primary Condition

Irritable bowel syndrome with diarrhea, hepatic encephalopathy

How it works

A poorly absorbed antibiotic that acts mainly inside the gut to reduce certain bacteria linked to symptoms.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Nausea
  • Increased liver enzymes
  • Dizziness
  • Fatigue
  • Swelling

Xifaxan FAQs

What is Xifaxan used for?

Xifaxan (rifaximin) is a prescription medication used to treat Irritable bowel syndrome with diarrhea, hepatic encephalopathy. A heavily advertised gut-targeted antibiotic used for IBS with diarrhea and to prevent confusion episodes from liver disease.

How does Xifaxan work?

A poorly absorbed antibiotic that acts mainly inside the gut to reduce certain bacteria linked to symptoms.

What are the common side effects of Xifaxan?

Commonly reported side effects of Xifaxan include Nausea, Increased liver enzymes, Dizziness, Fatigue, and Swelling. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Xifaxan have any serious warnings?

Xifaxan does not carry an FDA Boxed Warning, but every prescription medicine has risks and possible interactions. Always follow your doctor's instructions and read the medication guide that comes with it.

What is the generic name for Xifaxan?

The active ingredient in Xifaxan is rifaximin, which belongs to a class of medicines known as Gut-Selective Antibiotic.

Who makes Xifaxan?

Xifaxan is manufactured by Salix (Bausch Health). It was first approved in 2015.

How can I save money on Xifaxan?

You may be able to lower the cost of Xifaxan by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Xifaxan

Quick Facts

Manufacturer

Salix (Bausch Health)

Year Approved

2015

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