Zoloft

Black Box Warning

Generic: sertraline

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Information reviewed July 24, 2026

Rank #50 in US TV Ads
Class: SSRI (Antidepressant)

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What is it for?

One of the most prescribed and most-searched antidepressants, used for depression, anxiety disorders, OCD, and PTSD.

Primary Condition

Depression, anxiety, OCD, PTSD

How it works

An SSRI that increases serotonin levels in the brain by blocking its reuptake, improving mood and anxiety.

Common Side Effects

This is not a complete list of side effects. Always consult with a doctor.

  • Nausea
  • Sexual problems
  • Insomnia
  • Diarrhea
  • Suicidal thoughts in young adults

Zoloft FAQs

What is Zoloft used for?

Zoloft (sertraline) is a prescription medication used to treat Depression, anxiety, OCD, PTSD. One of the most prescribed and most-searched antidepressants, used for depression, anxiety disorders, OCD, and PTSD.

How does Zoloft work?

An SSRI that increases serotonin levels in the brain by blocking its reuptake, improving mood and anxiety.

What are the common side effects of Zoloft?

Commonly reported side effects of Zoloft include Nausea, Sexual problems, Insomnia, Diarrhea, and Suicidal thoughts in young adults. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Zoloft have any serious warnings?

Yes. Zoloft carries an FDA Boxed Warning — the agency's most serious safety warning. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.

What is the generic name for Zoloft?

The active ingredient in Zoloft is sertraline, which belongs to a class of medicines known as SSRI (Antidepressant).

Who makes Zoloft?

Zoloft is manufactured by Pfizer. It was first approved in 1991.

How can I save money on Zoloft?

You may be able to lower the cost of Zoloft by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.

Common questions about Zoloft

Other Mental Health medications

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Quick Facts

Manufacturer

Pfizer

Year Approved

1991

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