Zoryve

Zoryve (roflumilast) is a prescription medication used to treat Plaque psoriasis. A steroid-free topical treatment for plaque psoriasis, including hard-to-treat areas like skin folds.

A PDE4 inhibitor applied to the skin that reduces the inflammatory signaling involved in psoriasis.

Commonly reported side effects of Zoryve include Diarrhea, Headache, Application site pain, and Nausea. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Zoryve does not carry an FDA Boxed Warning, but every prescription medicine has risks and possible interactions. Always follow your doctor's instructions and read the medication guide that comes with it.

The active ingredient in Zoryve is roflumilast, which belongs to a class of medicines known as PDE4 Inhibitor (Topical).

Zoryve is manufactured by Arcutis Biotherapeutics. It was first approved in 2022.

You may be able to lower the cost of Zoryve by using a free pharmacy discount card or by comparing prices across pharmacies before you fill your prescription. Savings vary by pharmacy and location.