Eliquis vs Xarelto

A side-by-side look at two cardiovascular medications advertised on TV. Informational only — not medical advice.

Share

Information reviewed July 24, 2026

CA EliquisCA Xarelto
Generic nameapixabanrivaroxaban
Drug classFactor Xa InhibitorFactor Xa Inhibitor
TreatsBlood clots, atrial fibrillationBlood clots, atrial fibrillation
CategoryCardiovascularCardiovascular
ManufacturerBristol-Myers Squibb/PfizerBayer/Janssen
Year approved20122012
FDA warningBlack box warningBlack box warning
Est. TV ad spend$75M$28M
Common side effectsSerious bleeding risk, Bruising, Prolonged bleeding from cuts, Blood in urine or stoolSerious bleeding risk, Bruising, Prolonged bleeding, Dizziness

Frequently asked questions

Is Eliquis or Xarelto better?

Neither is universally "better." Eliquis (apixaban) and Xarelto (rivaroxaban) are both used for cardiovascular, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Eliquis and Xarelto?

Eliquis is a Factor Xa Inhibitor made by Bristol-Myers Squibb/Pfizer, while Xarelto is a Factor Xa Inhibitor made by Bayer/Janssen. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Eliquis has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

TVPills is independent and not affiliated with, endorsed by, or sponsored by any drug manufacturer or brand. All trademarks are the property of their respective owners. Some links are affiliate links; we may earn a commission at no extra cost to you.