Gardasil 9 vs Prevnar 20

A side-by-side look at two vaccine medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US Gardasil 9US Prevnar 20
Generic namehuman papillomavirus 9-valent vaccinepneumococcal 20-valent conjugate vaccine
Drug classVaccineVaccine
TreatsHPV-related cancer preventionPneumococcal disease prevention
CategoryVaccineVaccine
ManufacturerMerckPfizer
Year approved20142021
FDA warningNo boxed warningNo boxed warning
Est. TV ad spend
Common side effectsInjection-site pain, Swelling, Headache, FeverInjection-site pain, Muscle pain, Fatigue, Headache

Frequently asked questions

Is Gardasil 9 or Prevnar 20 better?

Neither is universally "better." Gardasil 9 (human papillomavirus 9-valent vaccine) and Prevnar 20 (pneumococcal 20-valent conjugate vaccine) are both used for vaccine, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Gardasil 9 and Prevnar 20?

Gardasil 9 is a Vaccine made by Merck, while Prevnar 20 is a Vaccine made by Pfizer. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Gardasil 9 has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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