Izervay vs Tyrvaya
A side-by-side look at two eye health medications advertised on TV. Informational only — not medical advice.
| US Izervay | US Tyrvaya | |
|---|---|---|
| Generic name | avacincaptad pegol | varenicline nasal spray |
| Drug class | Complement C5 Inhibitor | Nicotinic Acetylcholine Receptor Agonist (Nasal) |
| Treats | Geographic atrophy (advanced dry AMD) | Dry eye disease |
| Category | Eye Health | Eye Health |
| Manufacturer | Astellas Pharma | Viatris |
| Year approved | 2023 | 2021 |
| FDA warning | Moderate warnings | No boxed warning |
| Est. TV ad spend | — | — |
| Common side effects | Bleeding in the eye, Increased eye pressure, Floaters, Risk of eye infection | Sneezing, Cough, Throat irritation, Nose irritation |
Frequently asked questions
Is Izervay or Tyrvaya better?
Neither is universally "better." Izervay (avacincaptad pegol) and Tyrvaya (varenicline nasal spray) are both used for eye health, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.
What's the difference between Izervay and Tyrvaya?
Izervay is a Complement C5 Inhibitor made by Astellas Pharma, while Tyrvaya is a Nicotinic Acetylcholine Receptor Agonist (Nasal) made by Viatris. See the table above for a side-by-side breakdown.
Which one spends more on TV ads?
Izervay has the larger estimated TV advertising budget of the two.