Mounjaro vs Glucophage

A side-by-side look at two diabetes medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

CA MounjaroCA Glucophage
Generic nametirzepatidemetformin
Drug classGIP/GLP-1 Receptor AgonistBiguanide
TreatsType 2 diabetesType 2 diabetes
CategoryDiabetesDiabetes
ManufacturerEli LillyMerck/EMD (generic)
Year approved20221972
FDA warningBlack box warningBlack box warning
Est. TV ad spend$40M$2M
Common side effectsNausea, Diarrhea, Decreased appetite, VomitingNausea, Diarrhea, Abdominal discomfort, Vitamin B12 deficiency

Frequently asked questions

Is Mounjaro or Glucophage better?

Neither is universally "better." Mounjaro (tirzepatide) and Glucophage (metformin) are both used for diabetes, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Mounjaro and Glucophage?

Mounjaro is a GIP/GLP-1 Receptor Agonist made by Eli Lilly, while Glucophage is a Biguanide made by Merck/EMD (generic). See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Mounjaro has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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