Restasis vs Tyrvaya

A side-by-side look at two eye health medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US RestasisUS Tyrvaya
Generic namecyclosporine ophthalmic emulsionvarenicline nasal spray
Drug classCalcineurin Inhibitor (Eye Drop)Nicotinic Acetylcholine Receptor Agonist (Nasal)
TreatsChronic dry eyeDry eye disease
CategoryEye HealthEye Health
ManufacturerAbbVie (Allergan)Viatris
Year approved20032021
FDA warningNo boxed warningNo boxed warning
Est. TV ad spend$100M
Common side effectsBurning sensation, Eye redness, Watery eyes, Blurred visionSneezing, Cough, Throat irritation, Nose irritation

Frequently asked questions

Is Restasis or Tyrvaya better?

Neither is universally "better." Restasis (cyclosporine ophthalmic emulsion) and Tyrvaya (varenicline nasal spray) are both used for eye health, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Restasis and Tyrvaya?

Restasis is a Calcineurin Inhibitor (Eye Drop) made by AbbVie (Allergan), while Tyrvaya is a Nicotinic Acetylcholine Receptor Agonist (Nasal) made by Viatris. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Restasis has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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