Trelegy Ellipta vs Breztri Aerosphere

A side-by-side look at two respiratory medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US Trelegy ElliptaUS Breztri Aerosphere
Generic namefluticasone/umeclidinium/vilanterolbudesonide/glycopyrrolate/formoterol
Drug classInhaled Corticosteroid + LAMA + LABAInhaled Corticosteroid + LAMA + LABA
TreatsCOPD, asthmaCOPD
CategoryRespiratoryRespiratory
ManufacturerGSKAstraZeneca
Year approved20172020
FDA warningNo boxed warningNo boxed warning
Est. TV ad spend$200M$120M
Common side effectsThrush, Respiratory infections, Headache, CoughRespiratory infections, Thrush, Cough, Headache

Frequently asked questions

Is Trelegy Ellipta or Breztri Aerosphere better?

Neither is universally "better." Trelegy Ellipta (fluticasone/umeclidinium/vilanterol) and Breztri Aerosphere (budesonide/glycopyrrolate/formoterol) are both used for respiratory, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Trelegy Ellipta and Breztri Aerosphere?

Trelegy Ellipta is a Inhaled Corticosteroid + LAMA + LABA made by GSK, while Breztri Aerosphere is a Inhaled Corticosteroid + LAMA + LABA made by AstraZeneca. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Trelegy Ellipta has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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