Xarelto vs Crestor

A side-by-side look at two cardiovascular medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

CA XareltoCA Crestor
Generic namerivaroxabanrosuvastatin
Drug classFactor Xa InhibitorStatin
TreatsBlood clots, atrial fibrillationHigh cholesterol, cardiovascular prevention
CategoryCardiovascularCardiovascular
ManufacturerBayer/JanssenAstraZeneca
Year approved20122003
FDA warningBlack box warningNo boxed warning
Est. TV ad spend$28M$7M
Common side effectsSerious bleeding risk, Bruising, Prolonged bleeding, DizzinessMuscle pain, Headache, Liver problems, Weakness

Frequently asked questions

Is Xarelto or Crestor better?

Neither is universally "better." Xarelto (rivaroxaban) and Crestor (rosuvastatin) are both used for cardiovascular, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Xarelto and Crestor?

Xarelto is a Factor Xa Inhibitor made by Bayer/Janssen, while Crestor is a Statin made by AstraZeneca. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Xarelto has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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