Prednisone Side Effects

Common and serious side effects of Prednisone (prednisone), what to watch for, and when to call your doctor.

Share

Information reviewed July 24, 2026

Common side effects

This is not a complete list. Always consult a doctor or pharmacist.

  • Increased appetite and weight gain
  • Mood changes
  • High blood sugar
  • Insomnia
  • Bone thinning with long-term use

Serious warnings

Prednisone has notable warnings and precautions. Tell your doctor about your medical history and any other medicines or supplements you take before starting Prednisone.

When to call a doctor

As a general rule with any prescription medicine, contact your doctor about any side effect that is severe, persistent, or worries you. General guidance is to seek emergency care for signs of a serious allergic reaction to any medicine — such as trouble breathing or swelling of the face, lips, tongue, or throat.

The “Talk to a doctor” buttons are affiliate links to our telehealth partners Sesame and Lyla Health. TVPills may earn a commission. This is not medical advice.

TVPills is an informational reference, not medical advice. Always talk to a licensed healthcare provider about your treatment.

Frequently asked questions

What are the most common side effects of Prednisone?

Commonly reported side effects of Prednisone (prednisone) include Increased appetite and weight gain, Mood changes, High blood sugar, Insomnia, and Bone thinning with long-term use. This is not a complete list — tell your doctor or pharmacist about any side effects you experience.

Does Prednisone have any serious or boxed warnings?

Prednisone has notable warnings and precautions. Tell your doctor about your medical history and any other medicines or supplements you take before starting Prednisone.

When should I call my doctor about Prednisone side effects?

As a general rule with any prescription medicine, call your doctor about any side effect that is severe, doesn't go away, or worries you. General guidance is to seek emergency care for signs of a serious allergic reaction to any medicine — such as trouble breathing or swelling of the face, lips, tongue, or throat. For advice about your situation, talk to a licensed healthcare provider.

Where can I find the full list of Prednisone side effects?

The side effects above are commonly reported ones recorded for Prednisone (prednisone); they are not a complete list. For the full prescribing information and medication guide, check the official Prednisone label or ask your doctor or pharmacist.

Should I stop taking Prednisone if I have side effects?

General medical guidance is not to stop a prescription medicine on your own without talking to your doctor first. Your doctor can advise whether to continue, adjust, or change your treatment. This page is informational and not medical advice.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

TVPills is independent and not affiliated with, endorsed by, or sponsored by any drug manufacturer or brand. All trademarks are the property of their respective owners. Some links are affiliate links; we may earn a commission at no extra cost to you.