Cosentyx vs Stelara

A side-by-side look at two autoimmune medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US CosentyxUS Stelara
Generic namesecukinumabustekinumab
Drug classIL-17A Inhibitor (Biologic)IL-12/IL-23 Inhibitor (Biologic)
TreatsPlaque psoriasis, psoriatic arthritis, ankylosing spondylitisPsoriasis, Crohn's disease, ulcerative colitis
CategoryAutoimmuneAutoimmune
ManufacturerNovartisJanssen
Year approved20152009
FDA warningModerate warningsModerate warnings
Est. TV ad spend$160M$130M
Common side effectsRespiratory infections, Inflammatory bowel disease, Fungal infections, Injection site reactionsSerious infections, Headache, Fatigue, Injection site reactions

Frequently asked questions

Is Cosentyx or Stelara better?

Neither is universally "better." Cosentyx (secukinumab) and Stelara (ustekinumab) are both used for autoimmune, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Cosentyx and Stelara?

Cosentyx is a IL-17A Inhibitor (Biologic) made by Novartis, while Stelara is a IL-12/IL-23 Inhibitor (Biologic) made by Janssen. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Cosentyx has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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