Entresto vs Lisinopril
A side-by-side look at two cardiovascular medications advertised on TV. Informational only — not medical advice.
| US Entresto | US Lisinopril | |
|---|---|---|
| Generic name | sacubitril/valsartan | lisinopril |
| Drug class | ARNI (Neprilysin Inhibitor + ARB) | ACE Inhibitor |
| Treats | Chronic heart failure | High blood pressure, heart failure |
| Category | Cardiovascular | Cardiovascular |
| Manufacturer | Novartis | Various (generic) |
| Year approved | 2015 | 1987 |
| FDA warning | Black box warning | Black box warning |
| Est. TV ad spend | $150M | $1M |
| Common side effects | Low blood pressure, High potassium, Kidney problems, Dizziness | Dry cough, Dizziness, High potassium, Headache |
Lisinopril
Frequently asked questions
Is Entresto or Lisinopril better?
Neither is universally "better." Entresto (sacubitril/valsartan) and Lisinopril (lisinopril) are both used for cardiovascular, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.
What's the difference between Entresto and Lisinopril?
Entresto is a ARNI (Neprilysin Inhibitor + ARB) made by Novartis, while Lisinopril is a ACE Inhibitor made by Various (generic). See the table above for a side-by-side breakdown.
Which one spends more on TV ads?
Entresto has the larger estimated TV advertising budget of the two.