Humira vs Stelara

A side-by-side look at two autoimmune medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US HumiraUS Stelara
Generic nameadalimumabustekinumab
Drug classTNF Inhibitor (Biologic)IL-12/IL-23 Inhibitor (Biologic)
TreatsRheumatoid arthritis, psoriasis, Crohn's diseasePsoriasis, Crohn's disease, ulcerative colitis
CategoryAutoimmuneAutoimmune
ManufacturerAbbVieJanssen
Year approved20022009
FDA warningBlack box warningModerate warnings
Est. TV ad spend$500M$130M
Common side effectsSerious infections, Increased cancer risk, Allergic reactions, Injection site reactionsSerious infections, Headache, Fatigue, Injection site reactions

Frequently asked questions

Is Humira or Stelara better?

Neither is universally "better." Humira (adalimumab) and Stelara (ustekinumab) are both used for autoimmune, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Humira and Stelara?

Humira is a TNF Inhibitor (Biologic) made by AbbVie, while Stelara is a IL-12/IL-23 Inhibitor (Biologic) made by Janssen. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Humira has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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