Latuda vs Zoloft

A side-by-side look at two mental health medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US LatudaUS Zoloft
Generic namelurasidonesertraline
Drug classAtypical AntipsychoticSSRI (Antidepressant)
TreatsSchizophrenia, bipolar depressionDepression, anxiety, OCD, PTSD
CategoryMental HealthMental Health
ManufacturerSunovion (Sumitomo)Pfizer
Year approved20101991
FDA warningBlack box warningBlack box warning
Est. TV ad spend$85M$1M
Common side effectsSleepiness, Restlessness, Nausea, Movement problemsNausea, Sexual problems, Insomnia, Diarrhea

Frequently asked questions

Is Latuda or Zoloft better?

Neither is universally "better." Latuda (lurasidone) and Zoloft (sertraline) are both used for mental health, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Latuda and Zoloft?

Latuda is a Atypical Antipsychotic made by Sunovion (Sumitomo), while Zoloft is a SSRI (Antidepressant) made by Pfizer. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Latuda has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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