Nexium vs Somac

A side-by-side look at two gastrointestinal medications advertised on TV. Informational only — not medical advice.

Share

Information reviewed July 24, 2026

NZ NexiumNZ Somac
Generic nameesomeprazolepantoprazole
Drug classProton Pump Inhibitor (PPI)Proton Pump Inhibitor (PPI)
TreatsAcid reflux, GERD, stomach ulcersAcid reflux, GERD, ulcers
CategoryGastrointestinalGastrointestinal
ManufacturerAstraZenecaTakeda
Year approved20001997
FDA warningNo boxed warningNo boxed warning
Est. TV ad spend$6M$1M
Common side effectsHeadache, Diarrhea, Nausea, Abdominal painHeadache, Diarrhea, Nausea, Abdominal pain

Frequently asked questions

Is Nexium or Somac better?

Neither is universally "better." Nexium (esomeprazole) and Somac (pantoprazole) are both used for gastrointestinal, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Nexium and Somac?

Nexium is a Proton Pump Inhibitor (PPI) made by AstraZeneca, while Somac is a Proton Pump Inhibitor (PPI) made by Takeda. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Nexium has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

TVPills is independent and not affiliated with, endorsed by, or sponsored by any drug manufacturer or brand. All trademarks are the property of their respective owners. Some links are affiliate links; we may earn a commission at no extra cost to you.