Opdivo vs Tagrisso

A side-by-side look at two oncology medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US OpdivoUS Tagrisso
Generic namenivolumabosimertinib
Drug classPD-1 Inhibitor (Immunotherapy)EGFR Tyrosine Kinase Inhibitor
TreatsMultiple cancersEGFR-positive non-small cell lung cancer
CategoryOncologyOncology
ManufacturerBristol-Myers SquibbAstraZeneca
Year approved20142015
FDA warningModerate warningsModerate warnings
Est. TV ad spend$150M
Common side effectsImmune-related side effects, Fatigue, Rash, DiarrheaDiarrhea, Rash, Dry skin, Lung inflammation

Frequently asked questions

Is Opdivo or Tagrisso better?

Neither is universally "better." Opdivo (nivolumab) and Tagrisso (osimertinib) are both used for oncology, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Opdivo and Tagrisso?

Opdivo is a PD-1 Inhibitor (Immunotherapy) made by Bristol-Myers Squibb, while Tagrisso is a EGFR Tyrosine Kinase Inhibitor made by AstraZeneca. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Opdivo has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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