Repatha vs Lipitor

A side-by-side look at two cardiovascular medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US RepathaUS Lipitor
Generic nameevolocumabatorvastatin
Drug classPCSK9 Inhibitor (Biologic)Statin
TreatsHigh cholesterol, cardiovascular diseaseHigh cholesterol, cardiovascular prevention
CategoryCardiovascularCardiovascular
ManufacturerAmgenPfizer
Year approved20151996
FDA warningNo boxed warningNo boxed warning
Est. TV ad spend$120M$60M
Common side effectsInjection site reactions, Allergic reactions, Back pain, FatigueMuscle pain or weakness, Liver problems, Increased blood sugar, Memory problems

Frequently asked questions

Is Repatha or Lipitor better?

Neither is universally "better." Repatha (evolocumab) and Lipitor (atorvastatin) are both used for cardiovascular, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Repatha and Lipitor?

Repatha is a PCSK9 Inhibitor (Biologic) made by Amgen, while Lipitor is a Statin made by Pfizer. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Repatha has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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