Rinvoq vs Sotyktu

A side-by-side look at two autoimmune medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US RinvoqUS Sotyktu
Generic nameupadacitinibdeucravacitinib
Drug classJAK InhibitorTYK2 Inhibitor
TreatsRheumatoid arthritis, psoriatic arthritis, eczemaPlaque psoriasis
CategoryAutoimmuneAutoimmune
ManufacturerAbbVieBristol-Myers Squibb
Year approved20192022
FDA warningBlack box warningModerate warnings
Est. TV ad spend$175M$130M
Common side effectsSerious infections, Blood clots, Cardiovascular events, Cancer riskCommon cold symptoms, Increased infections, Cold sores, Mouth sores

Frequently asked questions

Is Rinvoq or Sotyktu better?

Neither is universally "better." Rinvoq (upadacitinib) and Sotyktu (deucravacitinib) are both used for autoimmune, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Rinvoq and Sotyktu?

Rinvoq is a JAK Inhibitor made by AbbVie, while Sotyktu is a TYK2 Inhibitor made by Bristol-Myers Squibb. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Rinvoq has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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