Tagrisso vs Calquence

A side-by-side look at two oncology medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US TagrissoUS Calquence
Generic nameosimertinibacalabrutinib
Drug classEGFR Tyrosine Kinase InhibitorBTK Inhibitor
TreatsEGFR-positive non-small cell lung cancerChronic lymphocytic leukemia and mantle cell lymphoma
CategoryOncologyOncology
ManufacturerAstraZenecaAstraZeneca
Year approved20152017
FDA warningModerate warningsModerate warnings
Est. TV ad spend
Common side effectsDiarrhea, Rash, Dry skin, Lung inflammationHeadache, Diarrhea, Bruising and bleeding, Infections

Frequently asked questions

Is Tagrisso or Calquence better?

Neither is universally "better." Tagrisso (osimertinib) and Calquence (acalabrutinib) are both used for oncology, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Tagrisso and Calquence?

Tagrisso is a EGFR Tyrosine Kinase Inhibitor made by AstraZeneca, while Calquence is a BTK Inhibitor made by AstraZeneca. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Tagrisso has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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