Taltz vs Rinvoq

A side-by-side look at two autoimmune medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US TaltzUS Rinvoq
Generic nameixekizumabupadacitinib
Drug classIL-17A Inhibitor (Biologic)JAK Inhibitor
TreatsPlaque psoriasis, psoriatic arthritis, ankylosing spondylitisRheumatoid arthritis, psoriatic arthritis, eczema
CategoryAutoimmuneAutoimmune
ManufacturerEli LillyAbbVie
Year approved20162019
FDA warningModerate warningsBlack box warning
Est. TV ad spend$190M$175M
Common side effectsInjection site reactions, Respiratory infections, Inflammatory bowel disease, Low white blood cell countSerious infections, Blood clots, Cardiovascular events, Cancer risk

Frequently asked questions

Is Taltz or Rinvoq better?

Neither is universally "better." Taltz (ixekizumab) and Rinvoq (upadacitinib) are both used for autoimmune, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Taltz and Rinvoq?

Taltz is a IL-17A Inhibitor (Biologic) made by Eli Lilly, while Rinvoq is a JAK Inhibitor made by AbbVie. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Taltz has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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