Taltz vs Tremfya

A side-by-side look at two autoimmune medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US TaltzUS Tremfya
Generic nameixekizumabguselkumab
Drug classIL-17A Inhibitor (Biologic)IL-23 Inhibitor (Biologic)
TreatsPlaque psoriasis, psoriatic arthritis, ankylosing spondylitisPlaque psoriasis, psoriatic arthritis
CategoryAutoimmuneAutoimmune
ManufacturerEli LillyJanssen
Year approved20162017
FDA warningModerate warningsModerate warnings
Est. TV ad spend$190M$140M
Common side effectsInjection site reactions, Respiratory infections, Inflammatory bowel disease, Low white blood cell countRespiratory infections, Headache, Injection site reactions, Joint pain

Frequently asked questions

Is Taltz or Tremfya better?

Neither is universally "better." Taltz (ixekizumab) and Tremfya (guselkumab) are both used for autoimmune, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Taltz and Tremfya?

Taltz is a IL-17A Inhibitor (Biologic) made by Eli Lilly, while Tremfya is a IL-23 Inhibitor (Biologic) made by Janssen. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Taltz has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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