Trintellix vs Vyvanse
A side-by-side look at two mental health medications advertised on TV. Informational only — not medical advice.
| US Trintellix | US Vyvanse | |
|---|---|---|
| Generic name | vortioxetine | lisdexamfetamine |
| Drug class | Serotonin Modulator (Antidepressant) | CNS Stimulant |
| Treats | Major depressive disorder | ADHD, binge eating disorder |
| Category | Mental Health | Mental Health |
| Manufacturer | Takeda/Lundbeck | Takeda |
| Year approved | 2013 | 2007 |
| FDA warning | Black box warning | Black box warning |
| Est. TV ad spend | $130M | $70M |
| Common side effects | Nausea, Sexual problems, Constipation, Vomiting | Decreased appetite, Insomnia, Dry mouth, Increased heart rate |
Trintellix
Frequently asked questions
Is Trintellix or Vyvanse better?
Neither is universally "better." Trintellix (vortioxetine) and Vyvanse (lisdexamfetamine) are both used for mental health, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.
What's the difference between Trintellix and Vyvanse?
Trintellix is a Serotonin Modulator (Antidepressant) made by Takeda/Lundbeck, while Vyvanse is a CNS Stimulant made by Takeda. See the table above for a side-by-side breakdown.
Which one spends more on TV ads?
Trintellix has the larger estimated TV advertising budget of the two.