Trulance vs Viberzi
A side-by-side look at two gastrointestinal medications advertised on TV. Informational only — not medical advice.
| US Trulance | US Viberzi | |
|---|---|---|
| Generic name | plecanatide | eluxadoline |
| Drug class | Guanylate Cyclase-C Agonist | Mu-Opioid Receptor Agonist |
| Treats | Chronic constipation and IBS-C | Irritable bowel syndrome with diarrhea |
| Category | Gastrointestinal | Gastrointestinal |
| Manufacturer | Salix (Bausch Health) | AbbVie |
| Year approved | 2017 | 2015 |
| FDA warning | Black box warning | Moderate warnings |
| Est. TV ad spend | — | — |
| Common side effects | Diarrhea, Should not be used in young children (boxed warning), Abdominal pain, Bloating | Constipation, Nausea, Abdominal pain, Risk of pancreatitis |
Frequently asked questions
Is Trulance or Viberzi better?
Neither is universally "better." Trulance (plecanatide) and Viberzi (eluxadoline) are both used for gastrointestinal, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.
What's the difference between Trulance and Viberzi?
Trulance is a Guanylate Cyclase-C Agonist made by Salix (Bausch Health), while Viberzi is a Mu-Opioid Receptor Agonist made by AbbVie. See the table above for a side-by-side breakdown.
Which one spends more on TV ads?
Trulance has the larger estimated TV advertising budget of the two.