Xarelto vs Vascepa

A side-by-side look at two cardiovascular medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US XareltoUS Vascepa
Generic namerivaroxabanicosapent ethyl
Drug classFactor Xa InhibitorOmega-3 Fatty Acid (EPA)
TreatsBlood clots, atrial fibrillationHigh triglycerides, cardiovascular risk reduction
CategoryCardiovascularCardiovascular
ManufacturerJanssen/BayerAmarin
Year approved20112012
FDA warningBlack box warningNo boxed warning
Est. TV ad spend$210M$90M
Common side effectsSerious bleeding risk, Bruising, Prolonged bleeding, Spinal/epidural blood clotsAtrial fibrillation, Bleeding risk, Joint pain, Swelling

Frequently asked questions

Is Xarelto or Vascepa better?

Neither is universally "better." Xarelto (rivaroxaban) and Vascepa (icosapent ethyl) are both used for cardiovascular, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Xarelto and Vascepa?

Xarelto is a Factor Xa Inhibitor made by Janssen/Bayer, while Vascepa is a Omega-3 Fatty Acid (EPA) made by Amarin. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Xarelto has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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