Xiidra vs Tyrvaya
A side-by-side look at two eye health medications advertised on TV. Informational only — not medical advice.
| US Xiidra | US Tyrvaya | |
|---|---|---|
| Generic name | lifitegrast | varenicline nasal spray |
| Drug class | LFA-1 Antagonist (Eye Drop) | Nicotinic Acetylcholine Receptor Agonist (Nasal) |
| Treats | Dry eye disease | Dry eye disease |
| Category | Eye Health | Eye Health |
| Manufacturer | Bausch + Lomb | Viatris |
| Year approved | 2016 | 2021 |
| FDA warning | No boxed warning | No boxed warning |
| Est. TV ad spend | $150M | — |
| Common side effects | Eye irritation, Unusual taste, Blurred vision, Eye discomfort on application | Sneezing, Cough, Throat irritation, Nose irritation |
Frequently asked questions
Is Xiidra or Tyrvaya better?
Neither is universally "better." Xiidra (lifitegrast) and Tyrvaya (varenicline nasal spray) are both used for eye health, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.
What's the difference between Xiidra and Tyrvaya?
Xiidra is a LFA-1 Antagonist (Eye Drop) made by Bausch + Lomb, while Tyrvaya is a Nicotinic Acetylcholine Receptor Agonist (Nasal) made by Viatris. See the table above for a side-by-side breakdown.
Which one spends more on TV ads?
Xiidra has the larger estimated TV advertising budget of the two.