Xtandi vs Verzenio

A side-by-side look at two oncology medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US XtandiUS Verzenio
Generic nameenzalutamideabemaciclib
Drug classAndrogen Receptor InhibitorCDK4/6 Inhibitor
TreatsProstate cancerHR+/HER2- breast cancer
CategoryOncologyOncology
ManufacturerAstellas/PfizerEli Lilly
Year approved20122017
FDA warningModerate warningsModerate warnings
Est. TV ad spend$90M$85M
Common side effectsFatigue, Hot flashes, High blood pressure, FallsDiarrhea, Low blood counts, Fatigue, Blood clots

Frequently asked questions

Is Xtandi or Verzenio better?

Neither is universally "better." Xtandi (enzalutamide) and Verzenio (abemaciclib) are both used for oncology, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Xtandi and Verzenio?

Xtandi is a Androgen Receptor Inhibitor made by Astellas/Pfizer, while Verzenio is a CDK4/6 Inhibitor made by Eli Lilly. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Xtandi has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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