Zepbound vs Contrave
A side-by-side look at two weight management medications advertised on TV. Informational only — not medical advice.
| US Zepbound | US Contrave | |
|---|---|---|
| Generic name | tirzepatide | naltrexone/bupropion |
| Drug class | GIP/GLP-1 Receptor Agonist | Opioid Antagonist / Aminoketone Combination |
| Treats | Chronic weight management, obstructive sleep apnea | Chronic weight management |
| Category | Weight Management | Weight Management |
| Manufacturer | Eli Lilly | Currax Pharmaceuticals |
| Year approved | 2023 | 2014 |
| FDA warning | Black box warning | Black box warning |
| Est. TV ad spend | $300M | — |
| Common side effects | Nausea, Diarrhea, Vomiting, Constipation | Nausea, Constipation, Headache, Increased blood pressure |
Frequently asked questions
Is Zepbound or Contrave better?
Neither is universally "better." Zepbound (tirzepatide) and Contrave (naltrexone/bupropion) are both used for weight management, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.
What's the difference between Zepbound and Contrave?
Zepbound is a GIP/GLP-1 Receptor Agonist made by Eli Lilly, while Contrave is a Opioid Antagonist / Aminoketone Combination made by Currax Pharmaceuticals. See the table above for a side-by-side breakdown.
Which one spends more on TV ads?
Zepbound has the larger estimated TV advertising budget of the two.