Contrave Side Effects
Common and serious side effects of Contrave (naltrexone/bupropion), what to watch for, and when to call your doctor.
FDA Boxed Warning
Contrave carries the FDA's most serious safety warning. Review the full prescribing information and discuss the risks with your doctor.
Common side effects
This is not a complete list. Always consult a doctor or pharmacist.
- Nausea
- Constipation
- Headache
- Increased blood pressure
- Suicidal thoughts (boxed warning, from bupropion)
Serious warnings
Contrave carries an FDA Boxed Warning — the agency's most serious safety alert. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.
When to call a doctor
As a general rule with any prescription medicine, contact your doctor about any side effect that is severe, persistent, or worries you. General guidance is to seek emergency care for signs of a serious allergic reaction to any medicine — such as trouble breathing or swelling of the face, lips, tongue, or throat.
The “Talk to a doctor” buttons are affiliate links to our telehealth partners Sesame and Lyla Health. TVPills may earn a commission. This is not medical advice.
Other Weight Management medications
Compare Contrave with other weight management drugs advertised on TV.
Frequently asked questions
What are the most common side effects of Contrave?
Commonly reported side effects of Contrave (naltrexone/bupropion) include Nausea, Constipation, Headache, Increased blood pressure, and Suicidal thoughts (boxed warning, from bupropion). This is not a complete list — tell your doctor or pharmacist about any side effects you experience.
Does Contrave have any serious or boxed warnings?
Contrave carries an FDA Boxed Warning — the agency's most serious safety alert. Read the full prescribing information and talk to your doctor about the risks before starting or changing treatment.
When should I call my doctor about Contrave side effects?
As a general rule with any prescription medicine, call your doctor about any side effect that is severe, doesn't go away, or worries you. General guidance is to seek emergency care for signs of a serious allergic reaction to any medicine — such as trouble breathing or swelling of the face, lips, tongue, or throat. For advice about your situation, talk to a licensed healthcare provider.
Where can I find the full list of Contrave side effects?
The side effects above are commonly reported ones recorded for Contrave (naltrexone/bupropion); they are not a complete list. For the full prescribing information and medication guide, check the official Contrave label or ask your doctor or pharmacist.
Should I stop taking Contrave if I have side effects?
General medical guidance is not to stop a prescription medicine on your own without talking to your doctor first. Your doctor can advise whether to continue, adjust, or change your treatment. This page is informational and not medical advice.