Auvelity vs Zoloft
A side-by-side look at two mental health medications advertised on TV. Informational only — not medical advice.
| US Auvelity | US Zoloft | |
|---|---|---|
| Generic name | dextromethorphan/bupropion | sertraline |
| Drug class | NMDA Antagonist / Aminoketone Combination | SSRI (Antidepressant) |
| Treats | Major depressive disorder | Depression, anxiety, OCD, PTSD |
| Category | Mental Health | Mental Health |
| Manufacturer | Axsome Therapeutics | Pfizer |
| Year approved | 2022 | 1991 |
| FDA warning | Black box warning | Black box warning |
| Est. TV ad spend | $50M | $1M |
| Common side effects | Dizziness, Headache, Diarrhea, Sleepiness | Nausea, Sexual problems, Insomnia, Diarrhea |
Frequently asked questions
Is Auvelity or Zoloft better?
Neither is universally "better." Auvelity (dextromethorphan/bupropion) and Zoloft (sertraline) are both used for mental health, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.
What's the difference between Auvelity and Zoloft?
Auvelity is a NMDA Antagonist / Aminoketone Combination made by Axsome Therapeutics, while Zoloft is a SSRI (Antidepressant) made by Pfizer. See the table above for a side-by-side breakdown.
Which one spends more on TV ads?
Auvelity has the larger estimated TV advertising budget of the two.