Eliquis vs Leqvio

A side-by-side look at two cardiovascular medications advertised on TV. Informational only — not medical advice.

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Information reviewed July 24, 2026

US EliquisUS Leqvio
Generic nameapixabaninclisiran
Drug classFactor Xa InhibitorsiRNA PCSK9-Lowering Therapy
TreatsBlood clots, atrial fibrillationHigh cholesterol, cardiovascular disease
CategoryCardiovascularCardiovascular
ManufacturerBristol-Myers Squibb/PfizerNovartis
Year approved20122021
FDA warningBlack box warningNo boxed warning
Est. TV ad spend$350M$90M
Common side effectsSerious bleeding risk, Bruising easily, Prolonged bleeding from cuts, Blood in urine or stoolInjection site reactions, Joint pain, Urinary tract infection, Shortness of breath

Frequently asked questions

Is Eliquis or Leqvio better?

Neither is universally "better." Eliquis (apixaban) and Leqvio (inclisiran) are both used for cardiovascular, but the right choice depends on your medical history, insurance and your doctor's guidance. This comparison is informational only.

What's the difference between Eliquis and Leqvio?

Eliquis is a Factor Xa Inhibitor made by Bristol-Myers Squibb/Pfizer, while Leqvio is a siRNA PCSK9-Lowering Therapy made by Novartis. See the table above for a side-by-side breakdown.

Which one spends more on TV ads?

Eliquis has the larger estimated TV advertising budget of the two.

TVPills

A reference tool to help identify prescription medications and supplements seen in television advertising. This is not medical advice. Always consult a healthcare professional.

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